2 edition of Molecular responses associated with the action of haemopoietic growth factors. found in the catalog.
Molecular responses associated with the action of haemopoietic growth factors.
Manchester thesis (Ph.D.), Faculty of Medicine.
|Contributions||University of Manchester. Faculty of Medicine.|
|The Physical Object|
|Number of Pages||393|
Thank you for your interest in spreading the word about The BMJ. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk : A Khwaja, A H Goldstone. Growth factors such as EGF, FGF, GDF, IGF, PDGF, and VEGF also affect hematopoietic stem cell differentiation. In addition, the fate of hematopoietic stem cells is modified by Activins, Bone Morphogenetic Proteins (BMPs), Hedgehog molecules, and Wnt-related molecules.
HEMATOPOIETIC GROWTH factors (HGFs) bind to specific cell surface receptors and rapidly activate cellular tyrosine kinases or intrinsic receptor tyrosine kinase many cases, the receptor itself becomes tyrosine phosphorylated, and phosphorylation sites in the receptor lead to recruitment of SH2 containing proteins that can activate downstream signaling pathways For example, the Cited by: Haemopoietic growth factors have for over two decades allowed experimentalists to grow haemopoietic bone marrow cells in vitro. With refinements in technique and the discovery of novel growth factors, all of the known haemopoietic lineages can now be grown in vitro. 6 Growth factors in haemopoiesis ALISON L. JONES JOHN L. MILLAR It has been Cited by:
Modes of Cell-Cell Signaling. Cell signaling can result either from the direct interaction of a cell with its neighbor or from the action of secreted signaling molecules (Figure ).Signaling by direct cell-cell (or cell-matrix) interactions plays a critical role in regulating the behavior of cells in animal example, the integrins and cadherins (which were discussed in the Cited by: 2. About this book The many different kinds of blood cells found in the human body are derived from multi-potential stem cells, which are induced to differentiate into one or another cell type by the action of regulatory proteins or growth factors.
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Stimulants, biochemical and molecular convergence on highly conserved cellular substrates and the programme of gene expression is seen. Introduction Proliferation of bone marrow haemopoietic precursors in vitro is dependent upon the presence of specific growth factors (reviewed by Dexter, ; Nicola & Vadas, ).Cited by: 2.
Abstract. Haemopoietic growth factors are involved in the production of the various blood cells from progenitors in the bone marrow, making them useful in a range of clinical situations.
The genes for several of them have been cloned and their production engineered by recombinant technology, making them widely by: 8.
The possibility of using haemopoietic growth factors as an adjunct to the treatment of severe infections is enticing, but designing a trial to evaluate this possibility is fraught with difficulties. Introduction. The mammalian haemopoietic system is composed of a number of different cell types, each with a specialised function.
These cells are present in the circulation and resident in the haemopoietic organs, principally the bone marrow and spleen. Over 99% of circulating blood cells are erythrocytes. In the absence of appropriate growth factors, for example interleukin-3 or GM-CSF, cultured bone marrow stem cells die by a process known as apoptosis or programmed cell death.
Apoptosis may occur in vivo when concentrations of specific growth factors are limiting and may be a means of regulating cell numbers.
Growth factors are also essential for proliferation of bone marrow Cited by: 7. Haemopoietic growth factors stimulate bone marrow cell division, differentiation, and survival in vivo.
We have investigated the use of recombinant human haemopoietic growth factors in vitro to improve cytogenetic by: 4. Haemopoietic growth factors are involved in the production of the various blood cells from progenitors in the bone marrow, making them useful in a range of clinical situations. Classification of these CSFs or growth factors, is based on the types of mature cells seen in colonies of bone marrow cells produced in vitro in response to these compounds.
Thus, interleukin 3 (IL-3) stimulates the production of mature cells of most of the haemopoietic lineages including granulocytes, macrophages, eosinophils, megakaryocytes Author: J. Scarffe, W. Steward, N. Testa, T.
Dexter. The Lancet Peptide Regulatory Factors HAEMOPOIETIC GROWTH FACTORS 2: CLINICAL APPLICATIONS Donald Metcalf Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, VictoriaAustralia OF the various haemopoietic growth factors that I discussed in the previous article in this series, only erythropoietin and the colony stimulating factors (CSFs) have reached the clinical by: The haemopoietic growth factors interleukin 3, granulocyte-macrophage colony-stimulating factor, granulocyte colony stimulating factor, macrophage colony-stimulating factor and erythropoietin act on haemopoietic cells to promote cell survival, proliferation, differentiation and maturation, as well as many functions of the mature by: 4.
MAST cells have a central role in allergic diseases mediated by specific immunoglobulin E antibody responses to allergens. results in the production of the haemopoietic growth factors Cited by: Haemopoiesis is regulated by a number of distinct growth factors, many of which have been purified to homogeneity and their genes cloned.
Some intriguing aspects of how these growth factors control the survival, proliferation and development of specific haemopoietic progenitor cells and their role in leukaemogenesis have now been by: Goldstone AH, Khwaja A. The role of haemopoietic growth factors in bone marrow transplantation.
Leuk Res. ; 14 (8)– Morstyn G, Campbell L, Souza LM, Alton NK, Keech J, Green M, Sheridan W, Metcalf D, Fox R. Effect of granulocyte colony stimulating factor on neutropenia induced by cytotoxic chemotherapy.
: A Khwaja, A H Goldstone. There is a great deal of functional overlap between hematopoietic growth factors (redundancy), and each growth factor has a multiplicity of biologic actions (pleiotropy). Thus more than one cytokine controls cells in any cell lineage, and most factors affect cells in more than one lineage.
Haemopoietic growth factors. Dexter TM. The growth and development of mature blood cells in vitro is supported by a series of glycoproteins with a range of biological activities. Many of these growth factors have been molecularly cloned, purified to homogeneity, Cited by: The haemopoietic growth factors interleukin-3 and colony-stimulating factor-1 stimulate proliferation but do not induce inositol lipid breakdown in murine bone-marrow-derived macrophages.
EMBO J. 5(12): Cited by: 1. haemopoietic growth factor receptors: relationships to biological function 1 10 Discussion W. Farrar, D. Ferris and D. Linnekin Haemopoietic growth factor regulation of protein kinases and genes associated with cell proliferation Discussion A.
Dunn and A. Wilks Contributions of autocrine and non-autocrine. Hematopoietic Growth Factors and Cancer-Associated VTE. Hematopoietic growth factor therapy plays an important role in the supportive care of patients with cancer. Erythropoiesis-stimulating agents (ESAs) can reduce the severity of anemia and transfusion requirements in patients with cancer, whereas granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating.
Influence of growth factors and substrates on differentiation of haemopoietic stem cells Anthony D Whetton and T Michael Dexter Paterson Institute for Cancer Research, Christie Hospital, and UMIST, Manchester, UK During the last few years there has been major progress in our understanding of the mechanisms underlying the regulation of haemopoietic stem cell proliferation and by: now also be solvable by the use of haemopoietic growth factors, andthese mayalso allowthe safer administration of more intensive treatments.
These growth factors regulate the production of the mature cellular constituents of the blood. They include specific granulocyte, macrophage, and granulocyte-macrophage colony stimulating factors;Author: A Khwaja, A H Goldstone. The clinical applications of Hematopoietic growth factor - GCSF Aruna Adusumilli1*,Ramakrishna Rao.
stimulating factors, cytokines, biological response modifiers are used in cancer recovery and enhancement of circulating blood cells is a new paradigm for molecular medicine.Dexter, T.M., Whetton, A.D. & Heyworth, C.M. The relevance of protein kinase C activation, glucose transport and ATP generation in the response of haemopoietic cells to growth factors.
In Oncogenes and growth control (ed. P. Kahn & T. Graf), pp. –Cited by: Hemopoietic growth factors regulate the differentiation and proliferation of particular progenitor available through recombinant DNA technology, they hold tremendous potential for medical uses when a person's natural ability to form blood cells is diminished or defective.
Recombinant erythropoietin (EPO) is very effective in treating the diminished red blood cell production that Angiopoietin: Agonists: Angiopoietin 1, Angiopoietin 4.